Hiperplasia estromal pseudoangiomatosa (HEP) de mama: a propósito de un caso / Pseudoangiomatous stromal hyperplasia (PASH) of the breast: about a case

La hiperplasia pseudoangiomatosa estromal de la mama es una patología benigna de rara aparición en mujeres, que hoy en día sigue generando incertidumbre en cuanto a su manifestación y al tratamiento definitivo. Nuestro objetivo será detallar el manejo y los resultados obtenidos luego de tratar a una paciente con esta patología atendida en hospital público durante la pandemia, que presentó gigantomastia bilateral a expensas de crecimiento y simetrización de mama contralateral afectada por HEP durante su estado gravídico.

Pseudoangimatous stromal hyperplasia of the breast, is a pathology of rare appearance, in women, which today continues to generate uncertainty regarding its manifestation and definitive treatment. Our objective will be to detail the management and results obtained after treating a patient with this pathology in a public hospital during a pandemic. who presented bilateral gigantomastia at the expense of growth and symmetrization of the contralateral breast affected by HEP during her pregnancy.

Outcomes after surgical resection of primary non-myxoma cardiac tumors

Abstract Objective: Primary cardiac tumors are rare lesions with different histological type. We reviewed our 17 years of experience in the surgical treatment and clinical results of primary non-myxoma cardiac tumors. Methods: Between July 2000 and February 2017, 21 patients with primary cardiac tumor were surgically treated in our institution. The tumors were categorized as benign non-myxomas and malignants. Data including the demographic characteristics, details of the tumor histology and grading, cardiac medical and surgical history, surgical procedure of the patients were obtained from the hospital database. Results: Eleven patients were diagnosed with benign non-myxoma tumor (male/female:7/4), ranging in age from 10 days to 74 years (mean age 30.9±26.5 years). Papillary fibroelastoma was the most frequent type (63.6%). There were two early deaths in benign group (all were rhabdomyoma), and mortality rate was 18%. The mean follow-up period was 69.3±58.7 months (range, 3 to 178 months). All survivals in benign group were free of tumor-related symptoms and tumor relapses. Ten patients were diagnosed with malignant tumor (sarcoma/lymphoma:8/2, male/female:3/7), ranging in age from 14 years to 73 years (mean age 44.7±18.9 years). Total resection could be done in only three (30%) patients. The mean follow-up period was 18.7±24.8 months (range, 0-78 months). Six patients died in the first 10 months. Conclusion: Complete resection of the cardiac tumors, whenever possible, is the main goal of surgery. Surgical resection of benign cardiac tumors is safe, usually curative and provides excellent long-term prognosis. On the contrary, malignant cardiac tumors still remain highly lethal.

Breast hamartoma: a clinicopathologic analysis of 27 cases and a literature review

OBJECTIVES: Breast hamartoma is an uncommon breast tumor that accounts for approximately 4.8% of all benign breast masses. The pathogenesis is still poorly understood and breast hamartoma is not a well-known disorder, so its diagnosis is underestimated by clinicians and pathologists. This study was designed to present our experience with breast hamartoma, along with a literature review. METHOD: We reviewed the demographic data, pathologic analyses and imaging and results of patients diagnosed with breast hamartoma between December 2003 and September 2013. RESULTS: In total, 27 cases of breast hamartoma operated in the Ankara University Medicine Faculty's Department of General Surgery were included in the study. All patients were female and the mean age was 41.8±10.8 years. The mean tumor size was 3.9±2.7 cm. Breast ultrasound was performed on all patients before surgery. The most common additional lesion was epithelial hyperplasia (22.2%). Furthermore, lobular carcinoma in situ was identified in one case and invasive ductal carcinoma was observed in another case. Immunohistochemical staining revealed myoid hamartoma in one case (3.7%). CONCLUSION: Breast hamartomas are rare benign lesions that may be underdiagnosed because of the categorization of hamartomas as fibroadenomas by pathologists. Pathologic examinations can show variability from one case to another. Thus, the true incidence may be higher than the literature indicates. .

Rapidly Growing Bilateral Pseudoangiomatous Stromal Hyperplasia of the Breast

A tumoral pseudoangiomatous stromal hyperplasia (PASH) that causes huge breast enlargement is very rare. Only two cases of huge tumoral PASHs have been reported in the English medical literature. We report here on a surgically confirmed case of bilateral huge tumoral PASH in a 47-year-old woman, and we present the imaging and histopathology findings. We also review the relevant medical literature.

Pseudoangiomatous stromal hyperplasia of the breast-cytological features of two cases and review of literature.

Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a lesion characterized on histology by the presence of anastomosing slit like spaces embedded in a hyalinized fibrous stroma. Till date, the cytological features of PASH have been described in only 12 cases, of which two cases were diagnosed on aspiration cytology as suspicious for carcinoma and in one case, for phyllodes tumor. We describe the FNAC findings of two of our cases of PASH. The first case was diagnosed as a phyllodes tumor and the other case as a benign proliferative breast disease, possibly a fibroadenoma. A review of the published literature on cytology of PASH shows the morphological variations that can exist in the cytology smears of this lesion. FNAC findings of PASH are non-specific, and the role of FNAC in PASH is to confirm the benign nature of the lesion, rather than provide a definitive pre-surgical diagnosis.

Angiomatosis of the breast in a male child. A case report with immunohistochemical analysis

Angiomatosis is a benign vascular lesion that has been described rarely in the breast. We describe a case in a seven-year-old boy of African descent who presented with progressively increasing, unilateral breast enlargement, the first such report in a male child. The patient underwent excisional biopsy of the breast mass followed by mastectomy. Pathologic examination revealed a diffuse proliferation of variably-sized, thin-walled vascular channels lined by flattened endothelium that showed negative immunohistochemical staining for von Willebrand factor, factor VIII-related antigen, CD34 and S-100 protein. There is no evidence of recurrence after 24 months of follow-up

Angiomatosis del tipo fístula arterio-venosa congénita del útero y pelvis / Angiomatosis type congenital arterio-venous fistula of the uterus and pelvis

Se describe un hamartoma vascular uterino tipo fístula arteriovenosa congénita en una mujer de 28 años. La lesión era multifocal en cuerpo uterino, cérvix y parametrios. Histológicamente, estaba compuesta por vasos con paredes en partes de tipo arterial, en parte venoso, y zonas de transición, con túnica muscular de grosor variable y lámina elástica interna discontinua. Esta morfología, similar a la de hamartomas vasculares tipo fístula arteriovenosa congénita del sistema nervioso central, apoya la posibilidad de un origen malformativo de la lesión

Hemangiomatosis a propósito de dos casos / Hemangiomatosis a purpose of a two cases

Se reportan dos casos de hemangiomatosis múltiple, ambos con compromiso del tracto gastrointestinal. El primero como hallazgo casual, el segundo mediante una laparotomía exploradora por hemorragia digestiva superior masiva y melena. Practicándose en ambos casos resección intestinal.

Caso de angiosarcoma de pelvis asociado a angiomatosis de columna / Case report of angiosarcoma of the pelvis associated to angiomatosis of the spine

El angiosarcoma primario de hueso es una lesión infrecuente que se asocia raramente con lesiones óseas, v. gr. solamente en dos casos se ha informado asociación con agiomatosis ósea. El caso que se presenta corresponde al de una mujer de 62 años con padecimiento de 11 meses de evolución caracterizado por incapacidad para la deambulación y la presencia de una masa en región glútea. En la autopsia se encontró un angiosarcoma originado en los huesos de la pelvis, con destrucción de la cresta ilíaca, del acetábulo y con extensión a tejidos blandos de la región glútea y del retroperitoneo; además mostró metástasis en cápsula renal izquierda y angiomatosis en cuerpos vertebrales

Angiomatosis retinae: (Enfermedad de Von Hippel) / Angiomatosis of the retina (Von Hippel Disease)

La angiomatosis de la retina ó Enfermedad de Von Hippel, es una patología que consiste en la presencia de un hamartoma angiomatoso que afecta al nervio óptico, retina o ambos, además de la posibilidad de afectación del Sistema Nervioso Central (SNC) y otros órganos, por lo cual entra dentro del grupo de las facomatosis. El siguiente es un reporte de un caso evaluado multidisciplinariamente en el Hospital Militar "Dr Carlos Arvelo" para descartar compromiso de un caso de Angiomatosis Retiniana referido a nuestro servicio

Angiolipomas múltiples / Multiple angiolipomas

Paciente con múltiples nódulos subcutáneos azulados y livedo reticular que planteó dificultades en el diagnóstico clínico de angiolipomas. La coloración azulada y el dolor pueden orientar en el diagnóstico diferencial con otras entidades

Angiomiolipoma del conducto genitourinario: problemas de diagnóstico diferencial, estudio clínico-patológico e inmunohistoquímico / Angiomyolipoma of the genital-urinary duct: diferential diagnostic problems, a clinical, pathological and immunohistochemical study

Se comunica la experiencia de los departamentos de anatomía patológica y urología del Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jal., con el angiomiolipoma renal en un periodo de 12 años (1981-1992). En ese lapso encontraron siete casos. De ellos seis fueron renales y uno testicular. En todos los pacientes con tumor de localización renal el tratamiento fue radical con nefrectomía total, incluyendo la glándula suprarrenal. En el caso del tumor testicular se realizó orquiectomía, incluyendo una porción de cordón espermático. Se discuten losproblemas de diagnóstico diferencial, clínicos, radiológicos y patológicos, así como la aplicación de anticuerpos monoclonales a lostejidos con inmunohistoquímica, específicamente para músculo liso que pueden ayudar a solventar los dilemas de diagnóstico histopatológico

Angiomatosis bacilar / Bacillary angiomatosis

La Angiomatosis Bacilar (AB) es una rara enfermedad infecciosa que afecta piel y vísceras de pacientes con el virus de inmunodeficiencia adquirida y otros inmunodeprimidos. Se caracteriza por presentar lesiones cutáneas vasculares asintomáticas que pueden diseminarse sistémicamente. El agente causal de la angiomatosis bacilar está estrechamente relacionada con la Rocha-limaea henselae

Angiomatosis bacilar / Bacillary angiomatosis

La angiomatosis bacilar (AB) es una rara enfermedad infecciosa bacteriana que afecta piel y vísceras de pacientes con el virus de inmunodeficiencia adquirida y otros inmunosuprimidos. Se caracteriza pro presentar tumores cutáneos vasculares asintomáticos que recuerdan al sarcoma de Kaposi y que pueden diseminarse sistémicamente. Mediante el uso de nuevas técnicas biológicas moleculares, recientemente se ha demostrado que el agente causal de la angiomatosis bacilar está estrechamente relacionado a la rochalimaea henselae. Nosotros presentamos un caso de angiomatosis bacilar para que los dermatólogos puedan tener un mayor conocimiento de esta enfermedad fácilmente tratable

Angiomatoid malignant fibrous histiocytoma of the eyelid.

A 20 year old female had an angiomatoid malignant fibrous histiocytoma of her left upper eyelid extending into the orbit, frontal and temporal regions. The tumor was excised and radiotherapy was given. Nine months follow-up did not reveal any recurrence.

Angiomatose epitelióide bacilar: outra infecçäo oportunística em pacientes com SIDA / Epitheloid bacillary angiotomasis: another oportunistic infection in AIDS

Os autores relatam um caso de pacientes-HIV-positivo com lesöes vasculares, cutâneas e ósseas, associadas à presença de agregados de microrganismos positivos na coloraçäo pelo método de Warthin-Starry. A tonalidade avermelhada e o aspecto pápulo-nodular das lesöes, assim como o quadro histológico de arranjo lobular dos vasos, circundados por células cuboidais de amplo citoplasma claro säo características da angiomatose epitelióide bacilar, entidade clínico-patológica recentemente individualizada em pacientes com SIDA. Trata-se de patologia infecciosa oportunística que responde à antibioticoterapia, mas pode apresentar curso potencialmente fatal

Von Hippel-Lindau disease without Lindau's tumour.

A case of Von Hippel-Lindau's disease lacking the classical Lindau's tumour is reported. The uncommon features of this case are highlighted and the relevant literature is briefly outlined.

Hamartoma melanocítico dérmico y facomatosis pigmento-vascular / Dermal melanocytic hamartona and pigmentary-vascular phacomatosis

El Hamartoma Melanocítico Dérmico es una displasia névica, caracterizada por la ubicación ectópica de melanocitos en dermis, en forma extensiva en napa y persistente. Es un cuadro de rara observación. Se comunican dos casos, uno de ellos asociado con una angiomatosis profusa, constituyendo lo que se conoce como Facomatosis Pigmento-vascular. Esta es una entidad malformativa variada donde, además de nevos melanocíticos, pigmentarios y vasculares, pueden existir malformaciones diversas